極低線量α線による姉妹染色分体交換と染色体異常の誘発

DOI
  • NAGASAWA Hatsumi
    Department of Env. and Rad. Health Sciences, Colorado State University
  • LITTLE John B.
    Center for Radiat.Sci. and Enviro.Health, Harvard School of Public Health

書誌事項

タイトル別名
  • Induction of sister chromatid exchanges (SCEs) and chromosomal aberrations by extremely low doses of α-particle irradiation

抄録

The bystander effect for chromosomal aberrations and SCEs was examined in Chinese Hamster cell lines deficient in either non-homologous end joining or homologous recombination.<BR> Dose-response curve for induction of chromosomal aberrations was curvilinear for all cell lines, with a great effect occurring at low fluences owing to aberrations arising in bystander cells. These aberrations were predominately of the chromatid type.<BR> We are presently examining the HR repair defective cell lines in different Rad 51 paralogs, as well as a cell line deficient in BRCA-2. The frequencies of SCEs measured in three non-irradiated wild type cell lines were approximately 0.3 SCE per chromosome, whereas only 0.16 SCE per chromosome was observed in two Rad 51C -/- cell lines. SCE frequencies significantly higher than the baseline line level were induced in wild type cells. On the other hand, induction of SCE was minimal or absent after α-particle irradiation in all of the mutant cell lines. These results suggest that Rad 51 paralogs may contribute to DNA damage repair processes involved in the induction of SCEs in bystander cells by very low fluences of α-Particles.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282680618578432
  • NII論文ID
    130007001289
  • DOI
    10.11513/jrrsabst.2007.0.3.0
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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