Application of DNA damage repair pathway for radiotherapy
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- TAUCHI Hiroshi
- Dept. Biological Sciences, Ibaraki University
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- FUNYU Yumi
- Dept. Biological Sciences, Ibaraki University
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- OHARA Maki
- Dept. Biological Sciences, Ibaraki University
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- SAKATA Koh-ichi
- Dept. Radiology, Sapporo Medical University
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- SOMEYA Masanori
- Dept. Radiology, Sapporo Medical University
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- SEKI Ryouta
- Dept. Biological Sciences, Ibaraki University
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- IIJIMA Kenta
- Dept. Biological Sciences, Ibaraki University
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- KOMATSU Kenshi
- Radiation Biology Center, Kyoto University
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- HAREYAMA Masato
- Dept. Radiology, Sapporo Medical University
Bibliographic Information
- Other Title
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- DNA損傷修復機構の治療戦略への応用
Abstract
Ionizing radiation induces various damages on genomic DNA. Among those, DNA double strand breaks (DSBs) are the most critical damage and it might be a main cause of cell killing in cancer radiotherapy. There are at least two pathways for DSBs, one is non-homologous end joining (NHEJ) and the other is homologous recombination (HR). We report here that the partial inhibition of the HR pathways has significant potential for application for improvement of cancer radiotherapy through the slight but enough radio-sensitization. A specific, strong inhibitor of any HR protein should be an effective radio-sensitizer because it shut down the S/G2 specific DSB repair pathway. However, this efficient inhibition of HR results a strong cytotoxicity, in other words, the inhibitor cannot reach the bed side, due to its strong side effects. Our novel concept is that inhibiting the function of a specific domain of a DSB repair protein can partially suppress HR pathway and reduce cancer cell viability following irradiation with slight but enough efficiency. This weak radio-sensitization can be enhanced if radiation is given with a sprit dose because the recovery from sublethal damage depends on HR.
Journal
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- The Japan Radiation Research Society Annual Meeting Abstracts
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The Japan Radiation Research Society Annual Meeting Abstracts 2011 (0), 9-9, 2011
The Japanese Radiation Research Society
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Details 詳細情報について
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- CRID
- 1390282680619383936
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- NII Article ID
- 130007001527
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed