Different Responses of Malignant Melanomas and Squamous Cell Carcinomas to X-rays and Heavy-ion Beams-II

  • AOKI Mizuho
    Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.
  • SHINO Yayoi
    Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.
  • NIE Jing
    Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.
  • FURUSAWA Yoshiya
    Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.
  • ANDO Koichi
    Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.

説明

It have been reported that malignant melanomas (MM) are resistant to conventional radiotherapy with low-LET radiations, but surprisingly responsible to the carbon ion-beam therapy at HIMAC. On the other hand, it is also known that squamous cell carcinomas (SCC) are resistant to both radiation therapies. To make clear the difference and utilizing the heavy-ion radiotherapy, the difference in the survival curves between the cell lines of MM and SCC were studied. Measurements of the radio-responses for the MM cells were started in the previous year, and that for SCC were added. The MM and SCC cell lines have exposed to carbon-ion beams (290 MeV/u, at the center of 6 cm-SOBP) at HIMAC. alpha/beta ratio and other survival parameters of the survival curves were analyzed. In case of MM, alpha/beta ratio increased when carbon beam was used compared with that for X-ray. But, in case of SCC, no clear difference was observed between carbon and X-rays. It means that carbon beam has advantage for MM on radiotherapy. [J Radiat Res 44:450 (2003)]

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390282680620410624
  • NII論文ID
    130005442957
  • DOI
    10.11513/jrrsabst.2003.0_450_2
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ