Different Responses of Malignant Melanomas and Squamous Cell Carcinomas to X-rays and Heavy-ion Beams-II
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- AOKI Mizuho
- Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.
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- SHINO Yayoi
- Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.
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- NIE Jing
- Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.
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- FURUSAWA Yoshiya
- Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.
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- ANDO Koichi
- Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.
説明
It have been reported that malignant melanomas (MM) are resistant to conventional radiotherapy with low-LET radiations, but surprisingly responsible to the carbon ion-beam therapy at HIMAC. On the other hand, it is also known that squamous cell carcinomas (SCC) are resistant to both radiation therapies. To make clear the difference and utilizing the heavy-ion radiotherapy, the difference in the survival curves between the cell lines of MM and SCC were studied. Measurements of the radio-responses for the MM cells were started in the previous year, and that for SCC were added. The MM and SCC cell lines have exposed to carbon-ion beams (290 MeV/u, at the center of 6 cm-SOBP) at HIMAC. alpha/beta ratio and other survival parameters of the survival curves were analyzed. In case of MM, alpha/beta ratio increased when carbon beam was used compared with that for X-ray. But, in case of SCC, no clear difference was observed between carbon and X-rays. It means that carbon beam has advantage for MM on radiotherapy. [J Radiat Res 44:450 (2003)]
収録刊行物
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- 日本放射線影響学会大会講演要旨集
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日本放射線影響学会大会講演要旨集 2003 (0), 450-450, 2003
一般社団法人 日本放射線影響学会
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