Microneedles Based Cellular Thermometer for Living Cells: A Novel Approach
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- MANI GANESH KUMAR
- 東海大 東海大学マイクロ・ナノ研究開発センター
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- PONNUSAMY DHIVYA
- 東海大 東海大学マイクロ・ナノ研究開発センター
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- 八十田 穣
- 東海大 総合理工学研究科 総合理工学専攻
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- 齋藤 飛鳥
- 東海大 工学研究科 機械工学専攻
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- 槌谷 和義
- 東海大 工学部 精密工学科
抄録
Cellular thermometry has a great demand in the clinical treatments and diagnosis of diseases. Microneedle type sensors gains more attention in contrast to conventional sensors due to its ability to penetrate the samples. As perforation takes only few seconds with microneedles, measurement and analysis could be quite simple. Besides that, the small dimensions of the sensor could be used for more precise measurements at single cell levels. In this work, microneedle based temperature sensor was developed to monitor the intercellular temperature. Microneedle was fabricated by simple electrochemical polishing of tungsten rod and temperature sensing electrodes was made u antimony (Sb) and sliver (Ag) by RF sputtering technique. The structural and morphological properties were analysed using XRD and FE-SEM. The microneedle tip size and angle was about 5 μm. The real time testing of the developed microneedle based temperature was employed to monitor the temperature of embryo of salmon fish and human lung cancer cells at controlled environment. The reported sensor here is totally reversible and results were reproducible after several routine testing.
収録刊行物
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- 精密工学会学術講演会講演論文集
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精密工学会学術講演会講演論文集 2017A (0), 939-940, 2017
公益社団法人 精密工学会
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詳細情報 詳細情報について
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- CRID
- 1390282680634606080
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- NII論文ID
- 130006434704
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可