ホモシステイン代謝における水溶性ビタミンの機能(若手シンポジウム「ビタミン基礎研究の進展を担う若手研究者たち」,<特集>ビタミン基礎研究の進展を担う若手研究者たち(第64回大会若手シンポジウム))
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- 山田 和弘
- Uniformed Services University of the Health Science, Department of Biochemistry
書誌事項
- タイトル別名
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- Action of Water-soluble Vitamins in Homocysteine Metabolism
- ホモシステイン代謝における水溶性ビタミンの機能
- ホモシステイン タイシャ ニ オケル スイヨウセイ ビタミン ノ キノウ
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Homocysteine is a non-protein-constituting amino acid. It is, however, one of the well-known amino acids as a biomarker. Hyperhomocysteinemia is a condition characterized by an elevated level of homocysteine in blood. Since hyperhomocysteinemia is reported as an independent risk factor for cardiovascular disease, a number of researches related to homocysteine metabolism have been reported. Many water-soluble vitamins act as a cofactor for homocysteine metabolism. Homocysteine is a metabolite of methionine, and it is involved in highly regulated folate and methionine metabolism. In this metabolism, homocysteine is one of the key metabolites. In this review,the function of vitamins in this important metabolism is described; especially focused on two enzymes, methionine synthase and methylenetetrahydrofolate reductase.
収録刊行物
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- ビタミン
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ビタミン 87 (1), 25-32, 2013
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390282680645803008
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- NII論文ID
- 110009578809
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 024249714
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可