Effect of co-supplementation of high dose of vitamin B_1 and fat on glucose and lipid metabolism in the porcine liver

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  • Oguma Atsushi
    Department of Food Science and Technology, Nippon Veterinary and Life Science University
  • Ashizawa Moe
    Department of Food Science and Technology, Nippon Veterinary and Life Science University
  • Egusa Saiga Ai
    Department of Food Science and Technology, Nippon Veterinary and Life Science University
  • Katayama Tsutomu
    Yamanashi Prefectural Livestock Experiment Station
  • Furuya Motohiro
    Yamanashi Prefectural Livestock Experiment Station
  • Akao Tomoyuki
    Yamanashi Prefectural Livestock Experiment Station
  • Nishimura Toshihide
    Department of Food Science and Technology, Nippon Veterinary and Life Science University

Bibliographic Information

Other Title
  • 高濃度ビタミンB_1と脂肪の同時摂取が豚肝臓中の糖質・脂質代謝に及ぼす影響
  • コウノウド ビタミン B ₁ ト シボウ ノ ドウジ セッシュ ガ ブタ カンゾウ チュウ ノ トウシツ ・ シシツ タイシャ ニ オヨボス エイキョウ

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Abstract

We examined the effects of vitamin B_1 (B_1) and fat added to a feed on their accumulation and glucose- and lipid-metabolism in the porcine liver. B_1 content in the livers of pigs fed a feed supplemented with 15 ppm B_1-supplemented feed (B+ group) was significantly higher than that in the livers of pigs fed the usual dosage of 1.5 ppm B_1 (Control group). B_1 content in the livers of pigs given a feed with 1.5 ppm B_1 plus 3% fat (F+ group) or a feed with 15 ppm B_1 plus 3% fat (B+F+ group) was significantly higher than that in pigs given a feed with 15 ppm B_1 (B+ group) or controls. The liver fat content in the B+F+ group was lower than that in the B+ group. Analysis of liver mRNA levels showed that gene expression of β-oxidation-related proteins increased in B_1-supplemented groups. Glycolytic pathway- and TCA cycle-related gene expression levels were also increased with fat supplementation. These results indicated that, in pigs with co-supplementation of high dose of B_1 and fat, glucose and lipid metabolism was enhanced in the liver.

Journal

  • VITAMINS

    VITAMINS 87 (10), 543-548, 2013

    THE VITAMIN SOCIETY OF JAPAN

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