Single nucleotide polymorphisms involved in metabolism and functions of retinoic acid : in cases of ALDH1A2 and RARβ

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  • Shidoji Yoshihiro
    Molecular & Cellular Biology, Graduate School of Human Health Science, University of Nagasaki

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  • レチノイン酸の代謝と機能にかかわる遺伝子多型 : ALDH1A2とRARβの場合(<特集>「ビタミンと遺伝子多型」-ビタミンA-)
  • レチノイン酸の代謝と機能にかかわる遺伝子多型 : ALDH1A2とRARβの場合
  • レチノインサン ノ タイシャ ト キノウ ニ カカワル イデンシ タケイ : ALDH1A2 ト RARv ノ バアイ

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Abstract

Few association studies on vitamin A and genetic polymorphism have been conducted so far, even though brilliant success has been achieved in translational researches on vitamin D receptor or methylene tetrahydrofolate reductase gene polymorphism. Recently, a couple of epoch-making papers have been published in vitamin A and genetic polymorphism field: 1) a common intronic single nucleotide polymorphism (SNP) (rs12591551 A/C) of the aldehyde dehydrogenase 1A2 (ALDH1A2) gene was shown to be associated with individual variations of retinoic acid concentrations in umbilical cord blood, and 2) two common intronic SNPs (rs6800566, rs13070407) of the retinoic acid receptor β (RARβ) gene were shown to be associated with individual variations of adaptive immune responses to measles vaccine. In this mini-review, these 2 pioneering works are introduced and discussed briefly.

Journal

  • VITAMINS

    VITAMINS 87 (10), 551-556, 2013

    THE VITAMIN SOCIETY OF JAPAN

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