Polymorphisms of transcobalamin II and vitamin B_<12>
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- Tanioka Yuri
- Department of Nutrition, Junior College of Tokyo University of Agriculture
Bibliographic Information
- Other Title
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- ビタミンB_<12>とtranscobalamin IIの一塩基多型(<特集>「ビタミンと遺伝子多型」-ビタミンB-)
- ビタミンB₁₂とtranscobalamin Ⅱの一塩基多型
- ビタミン B ₁ ₂ ト transcobalamin Ⅱ ノ ヒトシオキ タケイ
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Abstract
The transport of vitamin B_<12> (B_<12>) from food to cells depends on three B_<12>-binding proteins in mammals, haptcorrin (HC), intrinsic factor (IF), and transcobalamin II (TC II). The serum protein, TC II, transports B_<12> from the ileum to the tissue. The B_<12>-TC II complex (holoTC II) is then taken up into cells by receptor-mediated endocytosis. To date, at least 20 polymorphisms in the gene encoding TC II have been identified. Recently, the potential influence of TC II polymorphisms on serum holoTC II, serum B_<12>, methyl maronic acid (MMA), and total homocysteine (tHcy) status has been reported. This article summarizes the relationship between TC II polymorphisms and B_<12>-related markers, races, diseases, and structural changes in the protein.
Journal
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- VITAMINS
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VITAMINS 87 (8), 430-434, 2013
THE VITAMIN SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390282680646229760
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- NII Article ID
- 110009635555
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- NII Book ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL BIB ID
- 024854588
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed