Development of Assay Method for Plasma Concentration of Undercarboxylated Matrix Gla Protein (ucMGP), and Its Usefulness in Estimation of Vascular Vitamin K Status

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  • Tsugawa Naoko
    Department of Hygienic Sciences, Kobe Pharmaceutical University
  • Kanamori Kengo
    Department of Hygienic Sciences, Kobe Pharmaceutical University
  • Sawada Natsumi
    Department of Hygienic Sciences, Kobe Pharmaceutical University
  • Takase Tomoki
    Department of Hygienic Sciences, Kobe Pharmaceutical University
  • Nakayama Chie
    Department of Hygienic Sciences, Kobe Pharmaceutical University
  • Fujita Tomoko
    Department of Hygienic Sciences, Kobe Pharmaceutical University
  • Inoue Reika
    Department of Hygienic Sciences, Kobe Pharmaceutical University
  • Kingetsu Mao
    Department of Hygienic Sciences, Kobe Pharmaceutical University
  • Uchino Yuri
    Department of Hygienic Sciences, Kobe Pharmaceutical University
  • Shiraki Masataka
    Research Institute and Practice for Involutional Diseases
  • Okano Toshio
    Department of Hygienic Sciences, Kobe Pharmaceutical University

Bibliographic Information

Other Title
  • 血中低カルボキシル化Matrix Gla Protein (ucMGP)濃度測定法の開発と血管のビタミンK栄養評価における有用性の検討
  • チ ナカビク カルボキシルカ Matrix Gla Protein(ucMGP)ノウド ソクテイホウ ノ カイハツ ト ケッカン ノ ビタミン K エイヨウ ヒョウカ ニ オケル ユウヨウセイ ノ ケントウ

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Abstract

Matrix Gla protein (MGP) is known as a potent vascular calcification inhibitor. MGP is a vitamin K dependent protein (VKDP) which is activated by gamma-carboxylation of Glu residues (Gla) in the presence of vitamin K. It is considered that plasma concentration of undercarboxylated MGP (ucMGP) will be useful as the marker for vascular vitamin K status. However, a method to accurately quantify the plasma ucMGP concentration has not been well established. In present study, we have developed the assay method for plasma concentration of ucMGP, and which could be concluded to be a useful marker in the estimation of vascular vitamin K status.

Journal

  • VITAMINS

    VITAMINS 88 (3), 139-144, 2014

    THE VITAMIN SOCIETY OF JAPAN

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