書誌事項
- タイトル別名
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- The Study on Oxidative Stress Marker, Hydroxyoctadecadienoic Acid and 7-Hydroxycholesterol
- サンカ ストレスマーカー ト シテノ ヒドロキシリノールサン オヨビ 7 ヒドロキシコレステロール ニ カンスル ケンキュウ
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Lipid peroxidation products have received a great deal of attention for the practical application to clinical use as bio-markers. F2-isoprostanes from arachidonates and neuroprostanes from docosahexanoates have been proposed as bio-markers. Although these markers are formed by a free radical-mediated oxidation, the yields from the parent lipids are minimal. In contrast, hydroperoxyoctadecadienoates from linoleates and oxysterols from cholesterols are yielded by much simpler mechanisms from more abundant parent lipids in vivo. We proposed the method in which both free and ester forms of hydroperoxides and ketones as well as hydroxides of linoleic acid and cholesterol are measured as total hydroxyoctadecadienoic acid (tHODE) and 7-hydroxycholesterol (t7-OHCh), respectively. The concentrations of tHODE and t7-OHCh in physiological samples were much higher than that of 8-iso-prostagrandin F_<2α>. In addition to this advantage, hydrogendonor activity of antioxidants in vivo could be determined by the stereoisomeric-ratio of HODE.
収録刊行物
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- ビタミン
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ビタミン 81 (5-6), 213-221, 2007
公益社団法人 日本ビタミン学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282680677159296
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- NII論文ID
- 110006291280
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 8866863
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
