Polymorphisms of vitamin D binding protein gene and diseases

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  • Taketani Yutaka
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
  • Ohminami Hirokazu
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
  • Nakahashi Otoki
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
  • Ikeda Shoko
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School

Bibliographic Information

Other Title
  • ビタミンD結合タンパク質の遺伝子多型と疾患(<特集>「ビタミンと遺伝子多型」-ビタミンD-)
  • ビタミンD結合タンパク質の遺伝子多型と疾患
  • ビタミン D ケツゴウ タンパクシツ ノ イデンシ タケイ ト シッカン

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Abstract

Vitamin D binding protein (DBP), which is also known as a group-specific component (GC)-globulin, is a major plasma carrier protein for vitamin D and its metabolites. DBP is also known as an actin scavenger and a precursor of GC protein-derived macrophage activating factor (GC-MAF). This multifunction protein plays a role in the determination of serum 25-hydroxyvitamin D levels and regulation of the immune system. Therefore, genetic variants of DBP may affect risks of various diseases related with vitamin D levels and the immune system. Until now, various protein and genetic polymorphisms of DBP have been identified. Especially, Gc1S, Gc1F and Gc2 are well-known polymorphisms characterized by isoelectrophoresis, which are derived from two missense variants of DBP gene encoding D432E (rs7041) and T436K (rs4588). In this review, we discuss some relationships between DBP genotypes and common disease risk including osteoporosis, cancer and diabetes.

Journal

  • VITAMINS

    VITAMINS 87 (9), 506-513, 2013

    THE VITAMIN SOCIETY OF JAPAN

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