ビタミンD欠乏症の発症に関する遺伝子多型(<特集>第66回大会シンポジウム「栄養と臨床におけるビタミンの遺伝子多型に基づいたテーラーメイド摂取の有用性」)

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タイトル別名
  • Gene polymorphisms associated with vitamin D deficiency
  • ビタミンD欠乏症の発症に関する遺伝子多型
  • ビタミン D ケツボウショウ ノ ハッショウ ニ カンスル イデンシ タケイ

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抄録

Deficiency of vitamin D due to an insufficient intake of vitamin D and lack of sunshine exposure in childhood leads to diseases caused by vitamin D deficiency such as hypocalcemic seizures, rickets, infantile convulsion, bowlegs, short stature, and developmental motor skills disorder. Recently, the number of patients with vitamin D deficiency has been increased with changes in environmental factors. However, there are many cases of vitamin D deficiency which cannot be explained by the environmental factors alone. We have analyzed the genetic predisposition for the onset of vitamin D deficiency and have found differences in the polymorphisms or haplotypes of VDR, GC, and NADSYN1 genes in patients with vitamin D deficiency. Thus, genetic factors may predispose to vitamin D deficiency to some extent. Therefore, it has been thought that further examination is needed for establishment of tailor-made intake of vitamin D in the future.

収録刊行物

  • ビタミン

    ビタミン 89 (2), 72-74, 2015

    公益社団法人 日本ビタミン学会

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