書誌事項
- タイトル別名
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- Parkinson's Disease and B Vitamins : Association of Vitamin B_1 and Folate with The Pathogenesis
- 高齢者とB群ビタミン パーキンソン病とB群ビタミン--B1,葉酸と病態の関係を中心に
- コウレイシャ ト Bグン ビタミン パーキンソンビョウ ト Bグン ビタミン B1 ヨウサン ト ビョウタイ ノ カンケイ オ チュウシン ニ
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説明
We examined and reviewed the association between Parkinson's disease and vitamin B status. Thiamin triphosphate (TIP), but not thiamin, increased dopamine (DA) release from the rat striatum. We concluded that TTP could enhance the Na^+ permeability of the membrane, depolarize nerve cells, and sequentially cause a Ca^<2+> influx, inducing DA release. DOPA administration enhanced the elevation of serum homocysteine level. Hyperhomocysteinemia is considered to be a risk factor of Parkinson's disease as well as vascular diseases and Alzheimer's disease. Folate, vitamin B_<12>, or vitamin B_6 could potentially reduce the level of serum homocysteine. We reported that folate deficiency was not a rare condition in elderly neurological patients in Japan. They showed both peripheral and central nervous system disorders, including dementia. Folate supplementation had beneficial effects for two-thirds of the patients. Although further studies are needed, folate and other vitamins might have an inhibitory effect on the progression of Parkinson's disease.
収録刊行物
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- ビタミン
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ビタミン 80 (9), 449-456, 2006
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390282680677483136
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- NII論文ID
- 110004810195
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 8518594
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDLサーチ
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
