Rats fed a diet containing cyanocobalamin had less accumulation of vitamin B_<12> in the liver than those fed a diet containing methylcobalamin
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- Katsura Hiromi
- Department of Food and Nutrition, Kyoto Women's University
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- Koyama Katsushi
- Department of Nephrology, Kariya-Toyota General Hospital
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- Doi Yukio
- Department of Food and Nutrition, Kyoto Women's University
Bibliographic Information
- Other Title
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- ラット肝臓のビタミンB_<12>貯蔵量に与えるシアノコバラミンまたはメチルコバラミン経口投与の影響
- ラット カンゾウ ノ ビタミン B12 チョゾウリョウ ニ アタエル シアノコバラミン マタワ メチルコバラミン ケイコウ トウヨ ノ エイキョウ
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Abstract
The effect of orally administered cyanocobalamin and methylcobalamin on vitamin B_<12> storage in the rat liver and kidney was examined. Regardless of the dosage, the amount of vitamin B_<12> stored in the liver of rats fed the cyanocobalamin diet was about half of that in rats fed the methylcobalamin diets. In contrast, the amount of B_<12> accumulation in the kidney of rats fed the cyanocobalamin diet was higher than that in rats fed the methylcobalamin diet. Nevertheless, the proportions of four vitamin B_<12> analogues (hydroxo-, adenosyl-, cyano-, and methyl-cobalamin) stored in both organs were not affected by the type of cobalamin having different axial ligands in the diet. Moreover, the difference in the ligand type cobalamin in the diet did not affect the concentrations of circulating homocysteine and urinary methylmalonic acid. These results suggest that the storage capacity of vitamin B_<12> in the liver is determined by the type of the upper axial ligand of cobalamin in the diet.
Journal
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- VITAMINS
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VITAMINS 84 (11), 532-537, 2010
THE VITAMIN SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390282680677566080
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- NII Article ID
- 110007989344
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- NII Book ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL BIB ID
- 10913473
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed