Effect of vitamin E isoforms on glucose tolerance in mice fed a high-fat diet

  • Chikamatsu Izuho
    Department of Nutrition and Food Schience, Life Schiences, Graduate School of Humanities and Schiences, Ochanomizu University
  • Yoshihara Chizu
    Department of Nutrition and Food Schience, Life Schiences, Graduate School of Humanities and Schiences, Ochanomizu University
  • Yamashita Kaori
    Department of Nutrition and Food Schience, Life Schiences, Graduate School of Humanities and Schiences, Ochanomizu University
  • Akao Mai
    Department of Nutrition and Food Schience, Life Schiences, Graduate School of Humanities and Schiences, Ochanomizu University
  • Sonoda Mariko
    Department of Nutrition and Food Schience, Life Schiences, Graduate School of Humanities and Schiences, Ochanomizu University
  • Ishikawa Tomoko
    Institue of Environmental Science for Human Life, Ochanomizu University
  • Ikemoto Shinji
    Department of Human Nutrition, Seitoku University
  • Nishikawa Kahoko
    Institue of Environmental Science for Human Life, Ochanomizu University
  • Sone Yasuko
    Institue of Environmental Science for Human Life, Ochanomizu University
  • Ichi Ikuyo
    Department of Nutrition and Food Schience, Life Schiences, Graduate School of Humanities and Schiences, Ochanomizu University
  • Fujiwara Yoko
    Department of Nutrition and Food Schience, Life Schiences, Graduate School of Humanities and Schiences, Ochanomizu University

Bibliographic Information

Other Title
  • ビタミンE同族体が高脂肪食誘導性肥満マウスの耐糖能に及ぼす影響
  • ビタミン E ドウゾクタイ ガ コウシボウショク ユウドウセイ ヒマン マウス ノ タイトウノウ ニ オヨボス エイキョウ

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Abstract

We investigated the effect of vitamin E isoforms on the glucose tolerance in high-fat-induced obese mice. Eighteen male C57BL/6J mice aged six weeks were divided into three groups and fed a high-fat diet without vitamin E (HF), HF supplemented with 0.1% α-tocopherol (α-Toc) or HF supplemented with 0.1% γ-tocotrienol (γ-T3) for ten weeks. Oral glucose tolerance and insulin tolerance were tested after nine weeks of experimental diet feeding. Although growth rate and food intake were not significantly different among the three groups, addition of γ-T3, but not α-Toc, improved glucose tolerance and insulin sensitivity induced by the high-fat diet in obese mice. Fasting insulin levels in the γ-T3 group were lower than those in other high-fat groups, and the level of insulin secretion following glucose loading was significantly higher in the γ-T3 group than in the HF group. Histological findings showed that islets of the γ-T3 group were sufficiently active to secrete insulin in spite of high-fat feeding. These results suggested that γ-T3, but not α-Toc, protected islets against lipotoxicity and could be effective in treating type 2 diabetes.

Journal

  • VITAMINS

    VITAMINS 86 (12), 671-677, 2012

    THE VITAMIN SOCIETY OF JAPAN

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