Effects of Excessive Intake of Biotin on Nutritional State and Biomarkers in Immature Mice

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  • Nagai Yoshiko
    School of Human Science and Environment, University of Hyogo
  • Taniguchi Ayumi
    School of Human Science and Environment, University of Hyogo:Institute for Environmental and Gender Specific Medicine, Graduate School of Medicine, Juntendo University School of Medicine
  • Ohgushi Misa
    School of Human Science and Environment, University of Hyogo
  • Ebara Shuhei
    School of Human Science and Environment, University of Hyogo
  • Fukui Toru
    Clinical Laboratory, Byotai Seiri Laboratory
  • Watanabe Toshiaki
    School of Human Science and Environment, University of Hyogo

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Other Title
  • 幼若マウスにおけるビオチン過剰摂取による体内ビオチン動態および代謝マーカーへの影響
  • ヨウジャク マウス ニ オケル ビオチン カジョウ セッシュ ニ ヨル タイナイ ビオチン ドウタイ オヨビ タイシャ マーカー エノ エイキョウ

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Abstract

This study was conducted to elucidate the nutritional role of biotin. The excessive intake of biotin for 29 days did not induce any clinical signs such as dermatitis, alopecia and body weight change, in immature mice. In the group given excessive biotin, the relative weight (liver weight/body weight) was decreased and the percentage of free biotin was increased in the liver in the 1% biotin-supplemented group, although no blood biochemical and histological changes were found. Also there was no change of biotin concentration in the liver between groups given <0.5% biotin in the diet. However, serum concentration and urinary excretion of biotin was increased, indicating that the extra biotin in serum is easily eliminated from urine. From these findings it is suggested that the excessive intake of biotin may not induce severe nutritional influences in young mice.

Journal

  • VITAMINS

    VITAMINS 82 (11), 589-594, 2008

    THE VITAMIN SOCIETY OF JAPAN

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