Recent Progress in Coenzyme Q Research

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  • TAKAHASHI Takayuki
    Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
  • OKAMOTO Tadashi
    Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
  • KISHI Takeo
    Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University

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Other Title
  • コエンザイムQ研究の現状 : ビタミン類縁化合物に関する最近の研究
  • ビタミン類縁化合物に関する最近の研究 コエンザイムQ研究の現状
  • ビタミン ルイエン カゴウブツ ニ カンスル サイキン ノ ケンキュウ コエンザイム Q ケンキュウ ノ ゲンジョウ

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Abstract

Coenzyme Q (CoQ, Ubiquinone) is well-known to act as an essential carrier for the electron transfer from flavin proteins to the bc1 complex and concomitant trans-membrane transport of protons in the mitochondrial respiratory chain. However, COQ is found in all intracellular organelles and it appears to be provided by the endoplasmic reticulum-Golgi system as well as mitochondria. These observations suggest that intracellular CoQ may also have important physiological roles besides the mitochondrial respiratory chain. A greater part of CoQ widely distributed in intracellular organelles and serum is present as ubiquinol, the reduced form, and is suggested to act as an endogenous antioxidant. In addition, it is also suggested that COQ may be involved in activation of some uncoupling proteins, mitochondrial permeability transition, apoptosis and so on. This paper focuses on newly revealed physiological roles of CoQ in various biological systems.

Journal

  • VITAMINS

    VITAMINS 78 (12), 587-598, 2004

    THE VITAMIN SOCIETY OF JAPAN

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