Effects of repeated administrations of citalopram on noradrenergic neurons in the rat amygdala

DOI

Bibliographic Information

Other Title
  • シタロプラム慢性投与の扁桃体ノルアドレナリン神経系への作用

Description

TCitalopram was studied for its repeated effects on basal and handling-induced noradrenaline(NA) release in the rat basolateral amygdaloid nucleus(BLA). The repeated administrations of citalopram remarkably lowered the basal release of NA in the BLA to about 30% of those in the control rats. The handling stimuli failed to increase NA release in the rats treated with citalopram repeatedly. The present results indicate that the repeated administrations of citalopram result in a reduced activity of NA neurons and abolishment of stress-induced increase in NA release in the BLA. Inactivated NA neurons in the BLA could be implicated in the mechanism underlying the anxiolytic properties of citalopram.

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Details 詳細情報について

  • CRID
    1390282680690037376
  • NII Article ID
    130007022021
  • DOI
    10.11495/jkds.kds64.0.42.0
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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