カロリー制限模倣物質レスベラトロールによる脂肪細胞でのレジスチン遺伝子発現抑制
書誌事項
- タイトル別名
-
- A caloric restriction mimetic, resveratrol-mediated transcriptional repression of resistin gene in 3T3-L1 adipocytes.
説明
Resistin is a newly identified as a cysteine-rich adipose tissue-specific secretory adipokine that may link obesity and insulin resistance. We have studied the effect of resveratrol, a phytoalexne stilbene from grapes, on the regulation of resistin gene expression during 3T3-L1 adipogenesis. Resveratrol treatments attenuated adipocyte differentiation, which resulted in a dramatic decrease in resistin mRNA levels as well as its protein levels secreted into the culture medium in a dose-dependent fashion. In contrast, epigaro-catechin-3-gallate, a main polyphenoric compound of green tea leaf which has antioxidant potency same as resveratrol, did not repress resistin gene expression in the same dose-range. Transient transfection experiments with resistin promoter/luciferase reporter revealed that resveratrol reduced transcriptional activity of the resistin gene in a dose-dependent manner. These results indicate that the resistin gene expression is down-regulated by resveratrol through the reduction of gene transcription in 3T3-L1 adipocytes. [J Physiol Sci. 2007;57 Suppl:S89]
収録刊行物
-
- 日本生理学会大会発表要旨集
-
日本生理学会大会発表要旨集 2007 (0), 089-089, 2007
一般社団法人 日本生理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680704233472
-
- NII論文ID
- 130007038690
-
- データソース種別
-
- JaLC
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
