Distribution of histamine recepter in the gerbil retina
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- Imada Hideki
- Dept. Physiol. Sch. Med. fujita Health Univ. Toyoake Aichi, Japan
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- Kokubo Masahiro
- Joint Research Laboratory, Cooperation Use Study Room Facilities, Fujita Health Univ.
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- Kato Toshi-ake
- Dept. Clinical Laboratory Science, Fujita Health University College
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- Ohkuma Mahito
- Dept. Physiol. Sch. Med. fujita Health Univ. Toyoake Aichi, Japan
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- Miyachi Ei-ichi
- Dept. Physiol. Sch. Med. fujita Health Univ. Toyoake Aichi, Japan
Bibliographic Information
- Other Title
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- スナネズミ網膜におけるヒスタミンレセプターの分布
Abstract
In the central nervous system, histamine is known to act on three major types of G-protein-coupled receptors; histamine receptor 1 (HR1), histamine receptor 2 (HR2) and histamine receptor 3 (HR3). HR1 has been characterized in mammalian retinas. HR2 typically activated the signaling pathway. Histamine increased a GABA-mediated chloride current in amacrine cells from rat retinal slices via protein kinase A. Histamine via HR3 inhibited electrically-evoked dopamine release from the pig retina. Through electron microscopic technique and immunocytochemical staining methods, the localization of HR3, mGluR6 and GABA became apparent in ON-bipolar cell dendrites of the macaque retina, while HR1 and TH were localized in dopaminergic amacrine cells in the rat retina (Matthew et al., 2006).The gerbil is the animal which is characteristic to the central retinal artery. We have examined the localization of the histamine receptors in the gerbil retina using immunocytochemical method. The gerbils were perfused intracardially with a mixture of 4% paraformaldehyde in 0.1M sodium phosphate buffer. After the removed eyeballs were frozen with the rapid liquid nitrogen, they were cut with section of 10 μm using a cryostat. Experiments were performed to identify the targets of histaminergic retinopetal axons. We report the localization of histamine receptors in gerbil retinas by using light microscopic immunolabeling techniques. [J Physiol Sci. 2007;57 Suppl:S110]
Journal
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- Proceedings of Annual Meeting of the Physiological Society of Japan
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Proceedings of Annual Meeting of the Physiological Society of Japan 2007 (0), 110-110, 2007
PHYSIOLOGICAL SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390282680704277760
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- NII Article ID
- 130007038754
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed