EFFECTS OF SB334867 ON OREXIN-A MEDIATED FOOD AND WATER INTAKE IN THE BED NUCLEUS OF STRIA TERMINALIS

DOI
  • Hangodi Olga
    Neurophysiology Research Group of the Hungarian Academy of Sciences and Institute of Physiology, Pecs University, Medical School, Pecs, Republic of Hungary
  • Urban Barbara
    Neurophysiology Research Group of the Hungarian Academy of Sciences and Institute of Physiology, Pecs University, Medical School, Pecs, Republic of Hungary
  • Bagi Eva E
    Neurophysiology Research Group of the Hungarian Academy of Sciences and Institute of Physiology, Pecs University, Medical School, Pecs, Republic of Hungary
  • Fekete Eva
    Neurophysiology Research Group of the Hungarian Academy of Sciences and Institute of Physiology, Pecs University, Medical School, Pecs, Republic of Hungary
  • Toth Krisztian
    Neurophysiology Research Group of the Hungarian Academy of Sciences and Institute of Physiology, Pecs University, Medical School, Pecs, Republic of Hungary
  • Lenard Laszlo
    Neurophysiology Research Group of the Hungarian Academy of Sciences and Institute of Physiology, Pecs University, Medical School, Pecs, Republic of Hungary

書誌事項

公開日
2006
DOI
  • 10.14849/psjproc.2006.0.210.1
公開者
一般社団法人　日本生理学会

説明

Orexins are synthesized by lateral hypothalamic neurons which appear to have extensive projections throughout the neuraxis. Orexins have been shown to influence a variety of homeostatic mechanisms such as feeding and drinking behavior. Orexins act on two receptor subtypes, orexin-1 (OX1R) and orexin-2 (OX2R) receptors. Orexin-A (OXA) binds selectively to OX1R, whereas OX2R binds both OXA and orexin-B (OXB). The presence of OX1R in the bed nucleus of stria terminalis (BST) is verified. OXA microinjections into the BST evoked an increase in liquid food intake (FI) and water intake (WI) in a dose dependent manner. Here, the effect of selective OX1R antagonist SB334867 was examined in the BST in male Wistar rats. 0.26 nmol SB334867 was bilaterally microinjected into the BST alone or 15 min before 0.14 nmol OXA microinjections, whether the increases in liquid FI and WI following OXA applications can be antagonized. OXA enhanced liquid food consumption and increased WI as well. SB334867 pretreated OXA groups did not show any significant differences compared to the control groups neither in liquid food, nor in water ingestion. These findings show that the effects of OXA can be antagonized by SB334867 whereas SB334867 alone did not alter intakes indicating that the effects of OXA are mediated by OX1Rs in the BST.This work was supported by National Research Fund of Hungary (C012, M036687), and by the HAS. [J Physiol Sci. 2006;56 Suppl:S210]

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詳細情報 詳細情報について

  • CRID
    1390282680704690688
  • NII論文ID
    130007038917
  • DOI
    10.14849/psjproc.2006.0.210.1
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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