Lesions of the median preoptic nucleus abolish the increase in operant heat-escape/warm-seeking behavior after hypertonic-saline injection

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Other Title
  • 食塩負荷時の暑熱下行動性体温調節における正中視策前野破壊の影響

Description

We previously reported that s.c. hypertonic-saline increased operant heat-escape/warm-seeking behavior in rats. In this study, to assess the mechanism involved, the behavior was measured in rats of which the median preoptic nucleus (MnPO) was chemically ablated (ibotenic acid, 5 μg). The lesion was verified success by an attenuation of the drink after i.c.v. injection of angiotensin II. Thirty minutes after s.c. injection of either 2500- or 154-mM saline (1.0 ml/100 g), rats were successively placed at 26, 35 and 40°C for 1 h each. They could trigger 0°C-air for 45s when entered a specific area (i.e. operant behavior). In the sham-operated rats, counts of the operant behavior was greater (p<0.05) in 2500-mM than 154-mM saline during 35 and 40°C-heat. However, in the lesioned-rats, the counts did not differ between the two trials, and were at the same level as those in the sham-operated rats in 154-mM saline trial. These results suggest that the MnPO is involved in the mechanism which activates heat-escape/warm-seeking behavior after hypertonic-saline injection. Howeover, the MnPO is not associated with the behavior in euhydrated condition. [Jpn J Physiol 54 Suppl:S230 (2004)]

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Details 詳細情報について

  • CRID
    1390282680704875520
  • NII Article ID
    130005447216
  • DOI
    10.14849/psjproc.2004.0_s230_2
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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