Sham feedingは消化器系の動脈および前腕の血流を変化させる

We reported that the splanchnic blood flow increases within a minute after the beginning of a meal. To investigate the role of chewing and taste, we characterized responses in peripheral blood flow during sham feeding. After five minutes of baseline measurement in the over night fasting state, fifteen healthy subjects repeated chewing and expectorating 60 g solid meal for 4 minutes (sham feeding). We measured mean arterial pressure (MAP), blood velocity (BV) in celiac artery (CA), and blood flow (BF) in forearm. To assess the vascular resistance (VR), the MAP was divided by the BV in CA and the BF in forearm. The MAP did not significantly change throughout the trial. The BV in CA and the BF in forearm significantly decreased at the 1st minute of the sham feeding from the baseline (from 0.41 ± 0.02 to 0.37 ± 0.02 m/s, from 4.6 ± 0.8 to 2.6 ± 0.2 ml/min/100g tissue, mean ± SEM, p < 0.05). The VRs in CA and forearm significantly increased at the 1st minute of the sham feeding from the baseline (from 217 ± 14 to 246 ± 10 mmHg/m/s, from 26 ± 4 to 38 ± 4 mmHg/ml/min/100g tissue). The BV in CA significantly increased at the 3rd minute of the sham feeding from the baseline (from 0.41 ± 0.02 to 0.44 ± 0.03 m/s). These results suggest that the sham feeding, i.e., chewing and taste, increases BF in splanchnic organs without the arrival of chyme at corresponding organs. [J Physiol Sci. 2008;58 Suppl:S183]