Vitamin A and EEG delta power during sleep in mice.

Kitaoka Kazuyoshi, Hattori Atushi, Chikahisa Sachiko, Miyamoto Ken-ichi, Nakaya Yutaka, Sei Hiroyoshi

doi:10.14849/psjproc.2007.0_137_4

Bibliographic Information

Other Title

ビタミンAとマウスの睡眠デルタパワー

Description

Homeostatic mechanism of sleep is thought to have an essential role for rest and maintenance of neural function. Recent report has suggested that vitamin A (retinol and its derivatives) is involved in the electroencephalogram (EEG) delta oscillation during sleep. However, the evidence is not confirmed by other study. In this study, we attempted to record sleep EEG and behavior, and to quantify striatal monoamines for mice that fed vitamin A deficient (VAD) diet during four weeks, in order to clarify the linkage between delta oscillation and vitamin A. VAD mice demonstrated a significant decrease of delta power in EEG and spontaneous activity throughout 24-hour. And then, striatal dihydroxyphenylacetic acid, which is a metabolite of dopamine, was significantly decreased in VAD mice. Our results suggest that deficiency of vitamin A induces the attenuation of spontaneous activity and dopaminergic dysfunction. This decrease of spontaneous activity is considered to suppress the delta power in homeostatic manner, because 6-hour forced awaking caused the recovery of delta power in VAD mice up to that in the control. [J Physiol Sci. 2007;57 Suppl:S137]

Journal

Proceedings of Annual Meeting of the Physiological Society of Japan

Proceedings of Annual Meeting of the Physiological Society of Japan 2007 (0), 137-137, 2007

PHYSIOLOGICAL SOCIETY OF JAPAN

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Details 詳細情報について

CRID: 1390282680706296192

NII Article ID: 130005448981

DOI: 10.14849/psjproc.2007.0_137_4

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JaLC
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