Clinicopathological Study of Drug-induced Hypersensitivity Syndrome (DIHS)
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- Fukumoto Daisuke
- Department of Dermatology, Institute of Health Biosciences, University of Tokushima Graduate School
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- Ansai Shin-ichi
- Department of Dermatology, Institute of Health Biosciences, University of Tokushima Graduate School
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- Kubo Yoshiaki
- Department of Dermatology, Institute of Health Biosciences, University of Tokushima Graduate School
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- Hirose Kenji
- Department of Dermatology, Institute of Health Biosciences, University of Tokushima Graduate School
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- Matsudate Yoshihiro
- Tokushima Red Cross Hospital
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- Urano Yoshio
- Tokushima Red Cross Hospital
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- Arase Seiji
- Department of Dermatology, Institute of Health Biosciences, University of Tokushima Graduate School
Bibliographic Information
- Other Title
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- 薬剤性過敏症症候群（Drug-induced hypersensitivity syndrome）の臨床病理学的検討
- ヤクザイセイ カビンショウ ショウコウグン Drug induced hypersensitivity syndrome ノ リンショウ ビョウリガクテキ ケントウ
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Abstract
We performed a retrospective clinicopathological analysis of 22 cases of drug-induced hypersensitivity syndrome (DIHS) diagnosed in Tokushima University hospital and associated institutions during the past ten years. In twelve out of the 22 cases, lesions were induced by carbamazepine, in six cases, by zonisamide, and in one case each, by phenobarbital, mexiletine, allopurinol, or salazosulfapyridine. Histopathologically, we divided these cases into three subtypes, type I, type II, and type III. In ten of the 22 cases (46%), histopathological findings were compatible with type II, in four cases (18%), type III, and in eight cases (36%), type I. The age of onset in the IS type was significantly higher than that of EM type. Histopathologically, necroses of keratinocytes were more frequently observed in DIHS cases than in non-DIHS drug eruptions. There were no specific or common histopathological findings in DIHS. Therefore, we cannot differentiate DIHS from non-DIHS drug eruptions or viral eruptions only by histopathological findings. Our data indicate that type III is the most severe subtype followed by type II.
Journal
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- The Japanese Journal of Dermatology
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The Japanese Journal of Dermatology 120 (1), 23-29, 2010
Japanese Dermatological Association
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Details 詳細情報について
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- CRID
- 1390282680712609920
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- NII Article ID
- 130004708694
- 10028278843
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- NII Book ID
- AN00196602
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- ISSN
- 13468146
- 0021499X
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- NDL BIB ID
- 10529978
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed