Clinicopathological Study of Drug-induced Hypersensitivity Syndrome (DIHS)

Fukumoto Daisuke, Ansai Shin-ichi, Kubo Yoshiaki, Hirose Kenji, Matsudate Yoshihiro, Urano Yoshio, Arase Seiji

doi:10.14924/dermatol.120.23

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Other Title

薬剤性過敏症症候群（Drug-induced hypersensitivity syndrome）の臨床病理学的検討
ヤクザイセイカビンショウショウコウグン Drug induced hypersensitivity syndrome ノリンショウビョウリガクテキケントウ

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We performed a retrospective clinicopathological analysis of 22 cases of drug-induced hypersensitivity syndrome (DIHS) diagnosed in Tokushima University hospital and associated institutions during the past ten years. In twelve out of the 22 cases, lesions were induced by carbamazepine, in six cases, by zonisamide, and in one case each, by phenobarbital, mexiletine, allopurinol, or salazosulfapyridine. Histopathologically, we divided these cases into three subtypes, type I, type II, and type III. In ten of the 22 cases (46%), histopathological findings were compatible with type II, in four cases (18%), type III, and in eight cases (36%), type I. The age of onset in the IS type was significantly higher than that of EM type. Histopathologically, necroses of keratinocytes were more frequently observed in DIHS cases than in non-DIHS drug eruptions. There were no specific or common histopathological findings in DIHS. Therefore, we cannot differentiate DIHS from non-DIHS drug eruptions or viral eruptions only by histopathological findings. Our data indicate that type III is the most severe subtype followed by type II.

Journal

The Japanese Journal of Dermatology

The Japanese Journal of Dermatology 120 (1), 23-29, 2010

Japanese Dermatological Association

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