A Case of Nephrogenic Fibrosing Dermopathy

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  • 石灰沈着と経表皮的石灰排泄像を伴ったnephrogenic fibrosing dermopathy（NFD）の1例
  • セッカイ チンチャク ト ケイ ヒョウヒテキ セッカイ ハイセツゾウ オ トモナッタ nephrogenic fibrosing dermopathy NFD ノ 1レイ

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Abstract

Nephrogenic fibrosing dermopathy (NFD) is a recently described cutaneous fibrosing disorder associated with renal dysfunction. Recently, there have been many reports indicating that exposure to gadolinium-containing contrast agents during magnetic resonance imaging (MRI) studies may be involved. A 24-year-old man who had undergone peritoneal dialysis underwent a MRI study with gadolinium contrast (OmniscanTM) and developed NFD 6 days later. He developed indurated and hyperpigmented plaques like hard leather on his extremities. A histopathologic study revealed thickened collagen bundles a proliferation of fibroblasts, mucin deposition, and curled elastic fibers. Special features of our case included calcium deposition in the clefts, and transepidermal epidermal elimination of these deposits. We want to warn clinicians about the probable relationship between NFD and MR angiography using gadlinium-diethyrene diamine tetra acetic acid (Gd-DTPA).

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