A Case of Oral Lichen Planus Improved by Administration of Cepharanthin

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  • MURAKAMI YUKIO
    Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • KOMURA AKIKO
    Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • OKADA TOMOYUKI
    Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • KAWATA AKIFUMI
    Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • MATSUMURA MASAAKI
    Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • MARUYAMA NAOMI
    Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • OI YUICHI
    Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • TAMURA SEIKO
    Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • MACHINO MAMORU
    Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • KATAYAMA TADASHI
    Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry

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Other Title
  • セファランチン<sup>®</sup>の投与によって改善した口腔扁平苔癬の1例

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Description

Oral lichen planus is an intractable chronic inflammatory lesion with dyskeratosis, appearing more commonly on the buccal mucosa. Here we describe a case of oral lichen planus starting on the bilateral buccal mucosa in a 70-year-old female patient that showed great improvement. The patient's condition gradually improved after treatment with cepharanthin, an alkaloid agent extracted from Stephania cepharantha Hayata. A review of some additional literature pertaining to probable mechanisms of action is included.

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