A Study of the Influence of Temperature on the Stretch and Applied Weight of Ointments or Creams
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- Ohtani Michiteru
- Division of Hospital Pharmacy, Tokyo Postal Services Agency Hospital
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- Kagami Mai
- Division of Hospital Pharmacy, Tokyo Postal Services Agency Hospital
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- Nozawa Akane
- Division of Hospital Pharmacy, Tokyo Postal Services Agency Hospital
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- Matsumoto Mika
- Division of Hospital Pharmacy, Tokyo Postal Services Agency Hospital
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- Yamamura Yoshikazu
- Division of Hospital Pharmacy, Tokyo Postal Services Agency Hospital
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- Etoh Takashi
- Division of Dermatology, Tokyo Postal Services Agency Hospital
Bibliographic Information
- Other Title
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- 軟膏剤の伸展性・塗布量に及ぼす温度の影響
- ナンコウザイ ノ シンテンセイ ・ トフリョウ ニ オヨボス オンド ノ エイキョウ
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Abstract
The applied weight of an ointment or cream can influence its effects. In addition, the bases and formulations of an ointment or cream can have an impact on the applied weight. However, little is known about the tem perature effects on the applied weight, and few investigations of this effect have been reported. In order to evaluate the relationship between temperature and stretchiness or applied weight, we conducted experiments at 1°C or 30°C using a spread meter and healthy subjects. The stretchiness of oleaginous ointment bases was significantly increased by 2 times with a rise of temperature from 1°C to 30°C, and the yield values were decreased dramatically. The applied weights of oleaginous ointment bases were increased about 2 times with the rise of temperature. The stretchiness and applied weights of water-in-oil (W/O)-type emulsion bases were increased as well. In contrast, the yield values of water-soluble ointment bases and oil-in-water-type emulsion bases were decreased slightly, and applied weights were not changed. These results suggest that we should consider the change of stretchiness and applied weights of oleaginous ointment bases and W/O-type emulsion bases with changes in temperature in compliance instructions.
Journal
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- The Japanese Journal of Dermatology
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The Japanese Journal of Dermatology 122 (3), 613-618, 2012
Japanese Dermatological Association
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Details 詳細情報について
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- CRID
- 1390282680713166720
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- NII Article ID
- 130004708872
- 40019194121
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- NII Book ID
- AN00196602
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- ISSN
- 13468146
- 0021499X
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- NDL BIB ID
- 023513950
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed