Evaluation of the Efficacy of Topical Aluminum Chloride for Primary Palmar Hyperhidrosis in a Double-blind Examination

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  • 原発性手掌多汗症に対する二重盲験下での塩化アルミニウム外用剤の有効性の検討
  • ゲンパツセイシュショウタカンショウ ニ タイスル ニジュウ モウケンカ デ ノ エンカ アルミニウム ガイヨウザイ ノ ユウコウセイ ノ ケントウ

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In this study, we examined the efficacy and safety of topical aluminum chloride solution on palmar hyperhidrosis. The patients were 90 cases with moderate to severe primary palmar hyperhidrosis (sweating amount ≥0.5 mg/cm2/min) who visited Tokyo Medical and Dental University and Aichi Medical University from August of 2011 through January of 2012. They were randomly allocated to 3 groups given 20% aluminum chloride solution (hexahydrate), 50% aluminum chloride solution (hexahydrate) or placebo, and each solution was simply applied twice a day for 8 weeks using a double blind method. The measures for evaluation included sweating amount, HDSS (Hyperhidrosis disease severity scale) and DLQI (Dermatology life quality index). In addition, the improvement rates of objective and subjective symptoms were assessed. The 85 cases that completed the treatment were included in the alalysis. The groups given topical aluminum chloride solution showed significant, concentration-dependent decreases of the sweating amounts at the concentrations of 20% and 50% after 8 weeks. Subjective symptoms examined by HDSS and DLQI were also significantly improved after 2 weeks of external application. These results indicate that the topical 50% aluminum chloride solution applied to primary palmar hyperhidrosis decreased sweating significantly in comparison with patients treated with placebo. Irritant dermatitis on the skin adjacent to the sweating areas, such as on the interdigital area and dorsum of the hand other than the palm was locally observed as a concentration-dependent side effect, suggesting the necessity for a device to accurately apply the solution to only the affected area. Notably, the blood concentrations of aluminum chloride did not change in any of the patients, and no transfer inside the body was observed.

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