A Case of Pleomorphic Leiomyosarcoma with a Second Primary Sarcoma after Long Term Survival

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  • 長期生存し二次性肉腫を伴った多形型平滑筋肉腫（Pleomorphic leiomyosarcoma）の1例
  • チョウキ セイゾンシ 2ジセイ ニクシュ オ トモナッタ タケイガタ ヘイカツキン ニクシュ Pleomorphic leiomyosarcoma ノ 1レイ

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We report a 63-year-old man with a recurrent tumor on his upper back. The histopathological examination disclosed markedly pleomorphic areas mimicking malignant fibrous histiocytoma in addition to foci of fascicles consisting of smooth muscle cells. With the diagnosis of pleomorphic leiomyosarcoma (PLMS), he was treated with wide excision, chemotherapy, and radiation therapy. Ten years later, he visited our hospital because of a skin metastasis on his left elbow. A wide excisional biopsy showed a great amount of osteoclast-like giant cell infiltration in addition to the aforementioned PLMS histopathology. PLMS is a more aggressive variant of leiomyosarcoma. Despite the local recurrence and distant skin metastasis, our patient had a relatively long term survival. Furthermore, three years later, a second primary malignancy appeared on his upper back. It was diagnosed as myxoid liposarcoma.

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