16,17-dihydroxycyclooctatin, a new diterpene from Streptomyces sp. LZ35

  • Zhao Guishi
    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
  • Li Shanren
    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
  • Wang Yuanyuan
    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
  • Hao Huilin
    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
  • Shen Yuemao
    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
  • Lu Chunhua
    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University

書誌事項

タイトル別名
  • 16,17-dihydroxycyclooctatin, a new diterpene from <i>Streptomyces</i> sp.LZ35

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説明

Genome sequence analysis of Streptomyces sp. LZ35 has revealed a large number of secondary metabolite pathways, including a complete gene cluster for the biosynthesis of cyclooctatin. This cluster contains four genes, cotB1–4, located in a 5-kb region. Optimization of fermentation medium for LZ35Δheng (SR107) led to the identification of cyclooctatin (1) and 16,17-dihydroxycyclooctatin (2), a new diterpene. The structures of these substances were elucidated on the basis of 1D-, 2D-NMR, and HRESIMS data. Cytotoxicity against MDA-MB-231 and A549 cell lines was also evaluated. Results demonstrated that gene cluster and pathway analysis are key to guided isolation of new natural products.

収録刊行物

  • Drug Discoveries & Therapeutics

    Drug Discoveries & Therapeutics 7 (5), 185-188, 2013

    特定非営利活動法人 バイオ&ソーシャル・サイエンス推進国際研究交流会

詳細情報 詳細情報について

  • CRID
    1390282680714036608
  • NII論文ID
    130005054778
  • DOI
    10.5582/ddt.2013.v7.5.185
  • COI
    1:CAS:528:DC%2BC2cXks1Grsbs%3D
    1:STN:280:DC%2BC2c3gs1WhtA%3D%3D
  • ISSN
    1881784X
    18817831
  • PubMed
    24270382
  • Web Site
    https://search.jamas.or.jp/link/ui/2014281210
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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