The Effect of Application Order on Local and Systemic Adverse Reactions Using Corticosteroid Ointment and Moisturizers in Hairless Rats

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  • Ohtani Michiteru
    Department of Hospital Pharmacy, Tokyo Postal Services Agency Hospital
  • Matsumoto Mika
    Department of Hospital Pharmacy, Tokyo Postal Services Agency Hospital
  • Nozawa Akane
    Department of Hospital Pharmacy, Tokyo Postal Services Agency Hospital
  • Yamamura Yoshikazu
    Department of Hospital Pharmacy, Tokyo Postal Services Agency Hospital
  • Etoh Takashi
    Department of Dermatology, Tokyo Postal Services Agency Hospital

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  • ステロイド軟膏と保湿剤の併用による塗布順序が及ぼす局所および全身性副作用への影響
  • ステロイド ナンコウ ト ホシツザイ ノ ヘイヨウ ニ ヨル トフ ジュンジョ ガ オヨボス キョクショ オヨビ ゼンシンセイ フクサヨウ エ ノ エイキョウ

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Abstract

There are only a handful of reported studies on the order of applying corticosteroid ointments and moisturizers. Therefore, dermatologists and pharmacists instruct the application order according to experience. In our study, we applied corticosteroid ointment and moisturizers in different orders, and examined the relationship between the application order and adverse reactions in hairless rats. Body weight, weights of the spleen and adrenal gland, and thickness of the skin were selected as indications of adverse reactions. We applied corticosteroid ointment and moisturizer to the skin separately and also premixed them. Clobetasol propionate ointment was used as the corticosteroid ointment, and heparinoid and urea creams were used as the moisturizers. The results showed that the adverse reactions were independent of the order of application. In addition, there was no significant differences in adverse reactions when the corticosteroid ointment and moisturizer were mixed together before applying to the skin compared to layered applying.

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