A Clinicopathological Analysis of Granular Cell Tumor in the Dermis and Subcutaneous Fatty Tissue

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  • Koga Kaori
    Department of Pathology, Fukuoka University Hospital Sapporo Dermatopathology Institute
  • Kimura Tetsunori
    Sapporo Dermatopathology Institute
  • Ito Keigo
    Department of Dermatology, The Jikei University School of Medicine
  • Miyashita Aya
    Division of Dermatology, Omihachiman Community Medical Center

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Other Title
  • 皮膚および皮下脂肪組織に生じた顆粒細胞腫（Granular cell tumor）の臨床および病理組織学的検討
  • ヒフ オヨビ ヒカ シボウ ソシキ ニ ショウジタ カリュウ サイボウ シュ Granular cell tumor ノ リンショウ オヨビ ビョウリ ソシキガクテキ ケントウ

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Abstract

We performed a clinicopathological study of granular cell tumor (GCT) by reexamining the clinical data from 73 cases (74 lesions). The study included 23 male and 50 female patients. The average age at resection time was 45.4 years. The tumors were mostly located on the trunk (40%). No case had been clinically diagnosed as GCT; dermatofibroma was the most frequent clinical diagnosis. We examined the histological findings in 29 lesions. Epidermal hyperplasia was present in 74% (17/23 lesions), including 3 lesions with pseudoepitheliomatous hyperplasia. Nodular lymphocytic inflammatory infiltrates were seen in 28% (8/29 lesions). Small peripheral nerves surrounded by granular cells and intranuclear pseudo-inclusion bodies were observed respectively in 48% (14/29 lesions) and 83% (24/29 lesions). These findings support the hypothesis that GCT is a neural tumor.

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