A CASE STUDY OF LEUKOENCEPHALOPATHY OCCURRING DURING TREATMENT FOR APLASTIC ANEMIA

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  • KATO Izumi
    Department of Rehabilitation Medicine, Showa University School of Medicine
  • SATO Shinsuke
    Department of Rehabilitation Medicine, Showa University School of Medicine
  • KASAI Fumihito
    Department of Rehabilitation Medicine, Showa University School of Medicine
  • WATANABE Hideyasu
    Department of Rehabilitation Medicine, Showa University School of Medicine
  • WADA Shinichi
    Department of Rehabilitation Medicine, Showa University School of Medicine
  • INABA Hiroshi
    Department of Rehabilitation Medicine, Showa University School of Medicine
  • MIZUMA Masazumi
    Department of Rehabilitation Medicine, Showa University School of Medicine

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Other Title
  • 再生不良性貧血の治療中に発症した白質脳症へのリハビリテーション経験
  • 症例報告 再生不良性貧血の治療中に発症した白質脳症へのリハビリテーション経験
  • ショウレイ ホウコク サイセイ フリョウセイ ヒンケツ ノ チリョウ チュウ ニ ハッショウ シタ ハクシツ ノウショウ エ ノ リハビリテーション ケイケン

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Abstract

The patient was a 34-year-old woman. Combined ATG/CyA treatment was selected after the diagnosis of aplastic anemia, but leukoencephalopathy developed on day 10 of treatment, with right-hemiplegia and motor aphasia. The treatment was discontinued, but the disorders continued, and the patient was transferred to this hospital for rehabilitation. The functional independence measure (FIM) total score was 69 (motor score, 47; cognitive score, 22). Rehabilitation was conducted in conjunction with frequent blood transfusions for anemia and thrombocytopenia. Independent walking with the use of a T-top cane and a right side short leg brace was achieved, and the patient was discharged after 197 days of inpatient treatment. At the time of discharge, total FIM score was 109 (motor score, 81; cognitive score, 28). This patient had leukoencephalopathy of unknown cause and poor endurance, so it was difficult to set up a clear goal of rehabilitation based on prognosis with grounds.

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