Pear- and spindle-type tubular epithelial cells seen after radiation therapy

DOI
  • TSUKAHARA Yusuke
    Department of Central Clinical Laboratory, Tokyo Women’s Medical University Hospital
  • YOKOYAMA Takashi
    Department of Central Clinical Laboratory, Tokyo Women’s Medical University Hospital
  • OONUMA Eiko
    Department of Central Clinical Laboratory, Tokyo Women’s Medical University Hospital
  • ISODA Noriko
    Department of Central Clinical Laboratory, Tokyo Women’s Medical University Hospital
  • TAKAYAMA Saori
    Department of Central Clinical Laboratory, Tokyo Women’s Medical University Hospital
  • MIURA Hitomi
    Department of Central Clinical Laboratory, Tokyo Women’s Medical University Hospital
  • ISHIDA Hideki
    Department of Urology, Tokyo Women’s Medical University Hospital
  • TANABE Kazunari
    Department of Urology, Tokyo Women’s Medical University Hospital

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Other Title
  • 放射線療法で見られた洋梨・紡錘型尿細管上皮細胞

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Abstract

<p>The patient was a 30-year-old man. In July 2015, he was diagnosed with testicular cancer and treated with cisplatin-based chemotherapy (bleomycin etoposide, and platinol (BEP)). During the chemotherapy courses, typical renal tubular epithelial cells (RTECs) were found by urine sediment microscopy. The increased shed RTECs in urine was an evidence of nephropathy, which could be caused by the BEP chemotoxin to kidney. Because the BEP chemotherapy failed in the initial treatment, the patient was treated with radiation therapy further. After the radiation therapy, some pear- and spindle-type RTECs were found by urine sediment microscopy. These atypical shapes of RTECs could be caused by a side effect of radiation. In such a finding, pear- and spindle-type RTECs could be an evidence of radiation nephropathy. For an early diagnosis of radiation nephropathy, the pear- and spindle-type RTECs in urine sediment microscopy report could offer a valuable information to physicians for a differential diagnosis.</p>

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