Evaluation of chemiluminescence enzyme immunoassay of procalcitonin

DOI
  • OKUBO Manabu
    Department of Clinical Laboratory, Kawasaki Medical School Hospital
  • FURUKAWA Satoko
    Department of Clinical Laboratory, Kawasaki Medical School Hospital
  • MAEDA Hitomi
    Department of Clinical Laboratory, Kawasaki Medical School Hospital
  • ONO Kumi
    Department of Clinical Laboratory, Kawasaki Medical School Hospital
  • KASENO Setsuko
    Department of Clinical Laboratory, Kawasaki Medical School Hospital
  • UESUGI Satoe
    Department of Clinical Laboratory, Kawasaki Medical School Hospital
  • KOHGUCHI Katsunori
    Department of Clinical Laboratory, Kawasaki Medical School Hospital
  • TOHYAMA Kaoru
    Department of Clinical Laboratory, Kawasaki Medical School Hospital

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Other Title
  • ルミパルスプレスト ブラームスPCTの性能評価―RF高値検体における注意点―

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<p>Procalcitonin (PCT) is an important marker for the diagnosis of bacterial sepsis. In this study, we evaluated the basal performance of the recently developed PCT kit “Lumipulse Presto Brahms PCT”. The obtained within-run and between-day precisions were 1.1–2.0% and 3.3–3.5%, respectively. The obtained diluted linearity and lower limit of detection were 90.00 ng/mL and 0.003 ng/mL, respectively. Interference analysis showed that only RF negatively affected the assay results. PCT levels decreased to 14% at 24 hours and room temperature, in contrast to 5% at 4°C. The correlation coefficient (r) between this assay and the conventional assay was 0.991. The basal performance of the PCT kit is satisfactory and it could be used for measurement with high sensitivity. Results suggest that this kit is useful for the diagnosis of bacterial sepsis.</p>

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