Clinical Characteristics of Anti-aquaporin-4 Antibody-positive Optic Neuritis

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  • Ueki Satoshi
    Center for Integrated Human Brain Science, University of Niigata

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  • 抗アクアポリン4抗体陽性視神経炎の臨床的特徴

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This article relates to a lecture that was delivered on November 6 and 7, 2015 at the 53rd annual meeting of the Japanese Neuro-ophthalmology Society. Our study revealed the following clinical characteristics of anti-aquaporin-4 antibody-positive optic neuritis: poor visual prognosis, frequent recurrence, and high autoantibody positivity rates. Although about 60% of the patients treated using steroid pulse therapy had a poor visual outcome, the remaining 40% of patients had a better visual outcome. These results indicate that clinicians should treat anti-aquaporin-4 antibody-positive optic neuritis; not only to improve visual function in the acute phase, but also to prevent recurrence in the chronic phase. However, one problem that must be overcome is that it is difficult to assess the effects of various treatments for anti-aquaporin-4 antibody-positive optic neuritis, because the disease has a low incidence and widely varied visual prognoses.

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