Extraction of Apigenin and Luteolin from Leaves of Alfalfa (<i>Medicago sativa</i> L.) Using Mixtures of Liquid Carbon Dioxide and Ethanol
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- MISHIMA Kenji
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
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- KAWAMURA Hirofumi
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University Department of Seasoning & Foods Division, San-Ei Gen F.F.I.
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- KAWAKAMI Ryo
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
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- ITO Shota
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
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- INOUE Yuuta
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
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- HIROTA Tetsuya
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
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- HARADA Takunori
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
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- KATO Takafumi
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
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- SHARMIN Tanjina
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
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- MISUMI Makoto
- Department of Electronics Engineering and Computer Science, Faculty of Engineering, Fukuoka University
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- SUETSUGU Tadashi
- Department of Electronics Engineering and Computer Science, Faculty of Engineering, Fukuoka University
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- IRIE Keiichi
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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- MISHIMA Kenichi
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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- MUSTOFA Salim
- Research Center for Technology of Nuclear Industrial Material, Indonesia Nuclear Energy Agency
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- HASANAH Fauziyah
- Faculty of Science and Technology, Syarif Hidayatullah State Islamic University (UIN) Jakarta
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- SIREGAR Yusraini Dian Inayati
- Faculty of Science and Technology, Syarif Hidayatullah State Islamic University (UIN) Jakarta
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- ZAHARO Hilyatuz
- Faculty of Science and Technology, Syarif Hidayatullah State Islamic University (UIN) Jakarta
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- PUTRI Lily Surayya Eka
- Faculty of Science and Technology, Syarif Hidayatullah State Islamic University (UIN) Jakarta
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- SALIM Agus
- Faculty of Science and Technology, Syarif Hidayatullah State Islamic University (UIN) Jakarta
Bibliographic Information
- Other Title
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- Extraction of Apigenin and Luteolin from Leaves of Alfalfa (Medicago sativa L.) Using Mixtures of Liquid Carbon Dioxide and Ethanol
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Abstract
The extraction of apigenin and luteolin from the alfalfa leaves; Medicago sativa (L.) using mixtures of liquid carbon dioxide (CO2) was performed at 5, 20 and 25 ºC. The extraction pressure was from 8.5 to 14 MPa. The extraction yields were compared with yields obtained by other solvent extraction methods, such as pure liquid CO2 extraction and conventional alcohol (methanol or ethanol) extraction. We conducted qualitative and quantitative analyses for luteolin and apigenin in the extract using HPLC and analyzed the extraction behavior. The effect of three operating parameters, temperature, pressure and composition of ethanol in the liquid CO2 solution, on the extraction yield was investigated using the single-factor method. The yields of luteolin and apigenin in the extraction were significantly improved by adjusting the operating temperature and amount of ethanol in the liquid CO2 solution, whereas a change in the selectivity of the extract was not observed.
Journal
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- Solvent Extraction Research and Development, Japan
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Solvent Extraction Research and Development, Japan 22 (2), 177-186, 2015
Japan Association of Solvent Extraction
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Details 詳細情報について
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- CRID
- 1390282680719946752
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- NII Article ID
- 130005071512
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- NII Book ID
- AA11114608
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- ISSN
- 21884765
- 13417215
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- NDL BIB ID
- 026428538
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed