IMPACT OF CARDIOTHORACIC RATIO ON ALL-CAUSE AND CARDIOVASCULAR MORTALITY IN PATIENTS ON HEMODIALYSIS

DOI IR Web Site
  • YOSHIDA Noriyo
    Department of Internal Medicine, Showa University Northern Yokohama Hospital
  • OGATA Hiroaki
    Department of Internal Medicine, Showa University Northern Yokohama Hospital
  • YAMAMOTO Masahiro
    Department of Internal Medicine, Showa University Northern Yokohama Hospital
  • TAKESHIMA Akiko
    Department of Internal Medicine, Showa University Northern Yokohama Hospital
  • TAKESHIGE Yui
    Department of Internal Medicine, Showa University Northern Yokohama Hospital
  • KINUGASA Eriko
    Department of Internal Medicine, Showa University Northern Yokohama Hospital
  • AKIZAWA Tadao
    Department of Medicine, Division of Nephrology, Showa University School of Medicine
  • SHISHIDO Kanji
    Kawasaki Clinic Internal Medicine

Bibliographic Information

Other Title
  • 血液透析患者における心胸郭比と総死亡および心血管死亡リスクとの関連
  • ケツエキ トウセキ カンジャ ニ オケル シン キョウカクヒ ト ソウ シボウ オヨビ シンケッカン シボウ リスク ト ノ カンレン

Search this article

Description

Cardiovascular disease is the major cause of death in patients with chronic kidney disease and heart failure is the primary cause of death in patients on hemodialysis (HD) in Japan. It is important to control proper fluid volume and adjust Dry Weight (DW) to prevent cardiovascular event occurrence and progression in HD patients. Cardiothoracic ratio (CTR) is one of the useful indicators to evaluate DW. It is reported that CTR is independently associated with left ventricular hypertrophy and cardiac disturbance, but the clinical significance of CTR on the survival of HD patients remains unclear. We conducted a retrospective cohort study of 300 outpatients on HD in our affiliated institution from January 1 to December 31, 2006 to evaluate the influence of CTR on all-cause and cardiovascular mortality. The mean observation period was 4.59±1.93 years. The annual average CTR was divided into three equal groups. Kaplan-Meier analysis showed that all-cause mortality was significantly different in the 3 groups (P=0.0419, log-rank test). Spearman correlation analysis demonstrated that CTR was positively correlated with age, old myocardial infarction, serum phosphate, serum C-reactive protein and left ventricular mass index (LVMI) and CTR was negatively correlated with anemia and serum albumin. In multivariate analysis, male, hypoalbuminemia and LVMI were significantly associated with all-cause and cardiovascular mortality, but CTR was not significantly associated with either. CTR is not significantly associated with all-cause mortality or cardiovascular mortality in HD patients.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top