Cytogenetic Effects of N- (3', 4'-dimethxrycinnamoyl) Anthranilic Acid in Cultured Human Embryo Cells

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  • IWADARE MASANORI
    Tissue Culture Laboratory, Juntendo University, School of Medicine.
  • ENDO WAKAKO
    Tissue Culture Laboratory, Juntendo University, School of Medicine.
  • KAMIJO KIYOAKI
    Tissue Culture Laboratory, Juntendo University, School of Medicine.

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Other Title
  • N- (3', 4'-dimethoxycinnamoyl) Anthranilic Acidの培養 人胎児細胞に対する遺伝学的影響
  • N-(3′,4′-dimethoxycinnamoyl)Anthranilic Acidの培養人胎児細胞に対する遺伝学的影響
  • N 3 4 dimethoxycinnamoyl Anthranilic Ac

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Abstract

There is a growing concern that some of the drugs may produce genetic damage. Recently, many investigators have been reported that several drugs were added to the list of the chemicals capable of causing abnormalities in the chromosome of human somatic cells. The present study was undertaken to determine whether N- (3', 4'-dimethoxycinnamoyl) anthranilic acid (N-5'), a very effective anti-allergic agent, induced chromosome abnormalities in cultured human embryonic skin cells. As the results, there was no evidence for the increase of chromosome aberrations at a concentration of 200μg/ml or less. At 400μg/ml or higher, inhibition of cell growth was evident and these concentrations were unsuitable to observation of chromosome aberration in cultured embryonic skin cells.

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