Four therapeutic cases of RS3PE syndrome

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  • NAKAJIMA NAOYA
    Juntendo Tokyo geriatric medical center, Juntendo University School of Medicine. Geriatric General Medicine
  • FUKUDA YUKIKO
    Juntendo Tokyo geriatric medical center, Juntendo University School of Medicine. Geriatric General Medicine
  • YANG KWANG-SEOK
    Juntendo Tokyo geriatric medical center, Juntendo University School of Medicine. Geriatric General Medicine
  • AIBA MIYOJI
    Juntendo Tokyo geriatric medical center, Juntendo University School of Medicine. Geriatric General Medicine
  • TSUDA HIROSHI
    Juntendo Tokyo geriatric medical center, Juntendo University School of Medicine. Geriatric General Medicine

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Other Title
  • RS3PE症候群 (Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome) の自験4治療例
  • 症例報告 RS3PE症候群(Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome)の自験4治療例
  • ショウレイ ホウコク RS3PE ショウコウグン Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome ノ ジケン 4 チリョウレイ

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Abstract

RS3PE syndrome (Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome) is one of the disorders which present as polyarthritis. It is important to be aware of RS3PE syndrome when encountering elderly patients with polyarthritis who are negative for rheumatoid factor. We report 4 cases of RS3PE syndrome. All cases shared common clinical findings, such as acute onset, symmetrical polyarthritis, pitting edema of the hands and feet, and being negative for rheumatoid factor in serum. Treatment with corticosteroid was very effective in all cases. However, two patients showed a deteriorated clinical condition during the tapering of corticosteroid. Corticosteroid should be tapered off cautiously in patients with RS3PE syndrome.

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