CYTOKINE KINETICS IN PROLONGED LOW INTENSITY RUNNING AND THE EFFECT OF WHEAT GLUTEN HYDROLYSATE

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  • KAJISA TOMOKO
    DEPARTMENT OF HOSPITAL ADMINISTRATION, JUNTENDO UNIVERSITY FACULTY OF MEDICINE
  • WATANABE MASAYUKI
    DIVISION OF ART & SPORTS EDUCATIONAL SCIENCE, TOKYO GAKUGEI UNIVERSITY
  • OHTA MAKOTO
    DEPARTMENT OF HEALTH SCIENCE, DAITO BUNKA UNIVERSITY
  • IMANISHI AKIO
    DEPARTMENT OF HEALTH SCIENCE, DAITO BUNKA UNIVERSITY
  • HIRATA RYUZO
    CLINICAL LABORATORY, KATSUSHIKA MEDHICAL CENTER, THE JIKEI UNIVERSITY SCHOOL OF MEDICINE,
  • ANDO TAKASHI
    CLINICAL LABORATORY, KATSUSHIKA MEDHICAL CENTER, THE JIKEI UNIVERSITY SCHOOL OF MEDICINE,
  • SHIMIZU TOMOMI
    FACULTY OF BIOMEDICAL ENGINEERING, TOIN UNIVERSITY OF YOKOHAMA
  • SATO KENJI
    GRADUATE SCHOOL OF LIFE AND ENVIRONMENTAL SCIENCES, KYOTO PREFECTURAL UNIVERSITY
  • SUZUKI YOSHIO
    JUNTENDO UNIVERSITY GRADUATE SCHOOL OF HEALTH AND SPORTS SCIENCE
  • KOBAYASHI HIROYUKI
    DEPARTMENT OF HOSPITAL ADMINISTRATION, JUNTENDO UNIVERSITY FACULTY OF MEDICINE

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  • 低強度, 長時間持続する運動時のサイトカインの動態と小麦グルテン加水分解物Wheat Gluten Hydrolysate (WGH) 摂取による生体応答
  • テイキョウド,チョウジカン ジゾク スル ウンドウジ ノ サイトカイン ノ ドウタイ ト コムギ グルテン カスイブンカイブツ Wheat Gluten Hydrolysate(WGH)セッシュ ニ ヨル セイタイ オウトウ

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Abstract

Objective : To determine cytokine kinetics in prolonged low-intensity running and the effect of periodical wheat gluten hydrolysate (WGH) administration. Participants : Sixteen male runners who participated in a 24-hour running race. Methods : Participants were assigned randomly into group W (n=8), which consumed WGH (3g) every hour, and group P (n=8) which consumed indigestible dextrin at the same interval. Blood was sampled one hour before, and six hours and 12 hours afterthe start of the race. Then, cytokines (IL-6, TNF-α, and TGF-β1), glutamine (Gln), and creatine kinase (CK) were measured. Results : In group P, at 12 hours after the start of the race, compared to pre-race levels, IL-6 and CK increased and TNF-α decreased, while TGF-β1 was unchanged (p>0.05). Plasma Gln decreased significantly (p<0.05). On the other hand, in group W, at 12 hours after the start of the race, compared to one hour before, Gln levels were stable, and CK levels were constantly lower than that of group P. Furthermore, TNF-α (p<0.01) and TGF-β1 (p<0.05) levels decreased significantly. Conclusions : After prolonged low intensity running, IL-6 and CK levels increased while TNF-α and Gln levels decreased. From this result, the preceding increase of IL-6 levels may suppress the increase of TNF-α level. On the other hand, in group W, Gln levels were stable, and TNF-α and TGF-β1, which is regarded as a marker of fatigue, decreased significantly. Moreover, IL-6 and CK levels, which are closely related to inflammation, were lower than that of group P. Thus, in prolonged low intensity running, periodical WGH intake may have an anti-inflammatory effect and reduce fatigue.

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