Pre-congress: The effects of aging and exercise on protein acetylation/deacetylation: role of sirtuins

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  • RADAK ZSOLT
    Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University
  • MARTON ORSOLYA
    Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University
  • KOLTAI ERIKA
    Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University
  • GOTO SATARO
    Institute of Health and Sports Science and Medicine, Jutendo University
  • NAITO HISASHI
    Institute of Health and Sports Science and Medicine, Jutendo University

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  • The Effects of Aging and Exercise on Protein Acetylation/Deacetylation : Role of Sirtuins

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Irreversible posttranslational modifactions of proteins play a key role in cellular regulation. Acetylation/deacetyltion of lysine residues not just turning on or switching off proteins, but it significantly could effect ubiquitination of the same lysine residues, hence the degradation of proteins. Aging is associated with decreased level of protein turnover, and our data indicates that the acetylation level of proteins is increased with aging, which supports the link between acetylation level and protein stability. Exercise training counteracts with the effects of aging on acetylation level and on the regulation of sirtuins, which are powerful protein deacetylators.

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