Studies on Oncogenetic Effect of N-Methyl-n′-nitro-N-nitrosoguanidine in Experimental Animals.

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Other Title
  • N-methyl-N′-nitro-N-nitrosoguanidine投与による各種小動物の発生腫瘍差について
  • N-methyl-N′-nitro-N-nitrosoguanidine投与による各種小動物の発生腫瘍差について--特にPraomys(Mastomys)Natalensisの悪性リンパ腫について
  • N methyl N nitro N nitrosoguanidine トウヨ
  • Especially Producing Malignant Lymphoma in Praomys (Mastomys) natalensis
  • --特にPraomys (Mastomys) Natalensisの悪性リンパ腫について--

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Abstract

Sugimura et al (1967, 1970, 1971) made it possible to produce a gastric cancer in rats or dogs by oral administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In their studies it was found that this compound was able to produce various kinds of tumors not only in the stomach but also in other organs. Thus it becomes a subject of the experimental oncology to investigate various derivatives of this compound as for the carcinogenetic effect on organs of different animals. Each species of experimental animals was known to show different response to the same derivative, changing in the ratio and site of the oncogenesis. The author studied the ratio and site of the oncogenesis of MNNG in various species of small animals : Wistar rat, golden hamster, dd/I mouse and praomys (mastomys) natalensis. MNNG was given as the solution of drink water to these animals. The remarkable differences in the tumor growth in each species were found. In the rats cancers were detected in high degree in the glandular stomach, and in the hamsters many sarcomas and a few cancers were demonstrated in the glandular stomach. However in the seven autopsied mice no cancer were found. This fact is the conspicuous contrast to the results of the other authors who had showed the strong carcinogenetic effect of MNNG on the esophagus and the duodenum of the mouse. In the experiment of the mastomys, they were divided into two groups : the one group consisted of one and a half month old animals and the other, of twelve month old ones. In about half cases of the autopsied mastomys in both groups, malignant lymphomas were verified in the mesenterium. In the older group an adenoma of the adrenal gland and a fibrosarcoma of the genital organ were found to be associated with malignant lymphoma of the mesenterium. From these results it should be emphasized that the oncogenetic effect of the derivative was markedly different according to the species of the experimental animals. Although MNNG was administed to these animals in the same solvent through the same route, lymphoma was detected in the most of the mastomys and cancer was produced in the other small animals.

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