Development of mouse brain imaging environment using clinical 3-Tesla magnetic resonance scanner

DOI Web Site 13 References Open Access
  • Natsume Takahiro
    Faculty of Radiological Technology, Fujita Health University School of Health Sciences Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine
  • Hokamura Kazuya
    Department of Medical Education, Hamamatsu University School of Medicine
  • Makino Hiroshi
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine
  • Kimura Tetsuro
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine
  • Umemura Kazuo
    Department of Pharmacology, Hamamatsu University School of Medicine

Bibliographic Information

Other Title
  • 臨床用3T-MRI を用いたマウス脳イメージング環境の構築

Description

<p>The introduction of magnetic resonance imaging (MRI) in preclinical research requires the development of new MRI machines for both small animals, such as mice and rats, and larger animals, such as pigs and monkeys, and there is a substantial cost associated with the development of such machines. The objective of this study was to develop a mouse brain imaging environment using a mouse head coil and a clinical 3T-MRI machine. First, optimal acquisition parameters were determined by the phantom experiment. Next, T2-weighted images and magnetic resonance angiography (MRA) images were taken of mice in a mouse model of cerebral aneurysm. Sufficiently good quality T2-weighted images of the brain parenchyma over time were obtained, and major cerebral arteries and cerebral aneurysms were depicted with MRA. The imaging environment developed in this study achieved mouse brain imaging of sufficient quality without the need of a small animal MRI machine.</p>

Journal

References(13)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top