Development of mouse brain imaging environment using clinical 3-Tesla magnetic resonance scanner
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- Natsume Takahiro
- Faculty of Radiological Technology, Fujita Health University School of Health Sciences Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine
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- Hokamura Kazuya
- Department of Medical Education, Hamamatsu University School of Medicine
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- Makino Hiroshi
- Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine
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- Kimura Tetsuro
- Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine
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- Umemura Kazuo
- Department of Pharmacology, Hamamatsu University School of Medicine
Bibliographic Information
- Other Title
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- 臨床用3T-MRI を用いたマウス脳イメージング環境の構築
Description
<p>The introduction of magnetic resonance imaging (MRI) in preclinical research requires the development of new MRI machines for both small animals, such as mice and rats, and larger animals, such as pigs and monkeys, and there is a substantial cost associated with the development of such machines. The objective of this study was to develop a mouse brain imaging environment using a mouse head coil and a clinical 3T-MRI machine. First, optimal acquisition parameters were determined by the phantom experiment. Next, T2-weighted images and magnetic resonance angiography (MRA) images were taken of mice in a mouse model of cerebral aneurysm. Sufficiently good quality T2-weighted images of the brain parenchyma over time were obtained, and major cerebral arteries and cerebral aneurysms were depicted with MRA. The imaging environment developed in this study achieved mouse brain imaging of sufficient quality without the need of a small animal MRI machine.</p>
Journal
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- Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism)
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Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism) 27 (2), 235-241, 2016
The Japanese Society of Cerebral Blood Flow and Metabolism
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Keywords
Details 詳細情報について
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- CRID
- 1390282680732999552
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- NII Article ID
- 130007040639
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- ISSN
- 21887519
- 09159401
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed