Effects of driving restriction on the prescription of varenicline and success rate of smoking cessation treatment

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  • 自動車運転制限がバレニクリン処方および禁煙成功率に与えた影響

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Objective: To examine the effects of revision of the package insert of varenicline implemented in July 2011 to restrict hazardous machine operations, including driving, on the success of smoking cessation treatment.<br>Methods: The subjects were 126 patients who visited the smoking cessation clinic at our hospital. We examined the prescription rate of varenicline and nicotine patch and the success rate of smoking cessation before (October 2010 to June 2011) and after (July 2011 to January 2013) the revision.<br>Results: The prescription rate of varenicline showed a significant decrease from 92.6% before the revision to 79.2% after the revision. The success rate of smoking cessation was 74.1% (varenicline: 76%, nicotine patch: 50%) before the revision and 65.3% (varenicline: 70.2%, nicotine patch: 46.7%) after the revision, showing a tendency towards decrease, but no statistically significant difference.The most frequent reason for the choice of nicotine patch after the revision was the need for driving or machine operation (53.3%).<br>Discussion: It is natural that the prescription rate of varenicline showed a decrease with the above revision.The success rate of smoking cessation was not decreased significantly, but there is a possibility that the restriction which was stricter than that in other countries caused a decrease in the availability of smoking cessation aids, leading to disadvantages for patients.<br>Conclusion: While prescribing varenicline, driving and other operations should not be prohibited across the board, but permitted with reservations, as in other countries.

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