Predictive index for clinical response to nicotine patch

Nagano Asuka, Ohnishi Tsukasa, Iwasaki Mutsumi, Yamamoto Ayaka, Ishibashi Masaaki, Sagara Hironori, Iwamoto Sanju, Ishii Masakazu

doi:10.14950/jstc.12.82

Objective: We investigated the contributing factors for clinical response to the nicotine patch (Nicotinell^® TTS^®), a smoking cessation aid, and established a scoring system for predicting the clinical response to smoking cessation therapy.Methods: We investigated clinical factors from the medical records of patients treated with nicotine patches from the smoking cessation clinic. We separated the patients (n = 70) into the success group and the failure group according to the outcome of the 12-week treatment, and then analyzed the clinical factors from medical records.Results/Findings: The 12-week failure rate was 47.1% (33/70 patients). Multivariate stepwise logistic regression analysis revealed that TDS (Tobacco Dependence Screener) and psychiatric disease in underlying disease were significant factors that independently contributed to a negative response, with odds ratios of 1.736 (per point of TDS score), and 5.587 (no vs. yes, psychiatric disease), respectively. A predictive index (PI) of clinical response to the nicotine patch in patients was calculated using the regression coefficients of these two factors as an integer, and the index was significantly higher for the failure group than for the success group.Conclusion: The obtained PI may represent an appropriate scoring system for predicting the responses to nicotine patches in these patients.

Predictive index for clinical response to nicotine patch

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