Relationship between Serum Ascorbic Acid, Serum Type IV Collagen and Urinary Albumin Excretion in Diabetes

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  • OTA Akio
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • NISHIKAWA Masato
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • SATO Hiroshi
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • KOGA Atsushi
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • SHIMIZU Makoto
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • HOSHI Kenji
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • SAITO Nobuhiko
    The Third Department of Internal Medicine, St. Marianna University School of Medicine

Bibliographic Information

Other Title
  • 糖尿病患者における血清アスコルビン酸とIV型コラーゲンおよび尿中アルブミン排泄量の検討
  • 糖尿病患者における血清アスコルビン酸と4型コラーゲンおよび尿中アルブミン排泄量の検討
  • トウニョウビョウ カンジャ ニ オケル ケッセイ アスコルビンサン ト 4ガタ

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Abstract

Capillary basement membrane thickening is a characteristic of diabetic microangiopathy. Type IV collagen is the major component of basement membrane. To elucidate the pathogenesis of diabetic nephropathy, we investigated serum type IV collagen and serum ascorbic acid in non-insulin-dependent diabetes mellitus (NIDDM) (n=37) and in normal subject s (n=14). Serum ascorbic acid level was lower in NIDDM than in normal subjects. Serum type IV collagen level was higher in NIDDM than in normal subjects. There was a significant positive correlation between serum type IV collagen and HbA_<IC> in poorly controlled diabetes (HbA_<IC>>8%) (p<0.05). A significant negative correlation was found between serum type IV collagen and serum ascorbic acid (p<0.05). A significant positive correlation was found between serum type IV collagen and urinary albumin excretion in patients with microalbuminuria (U-alb>30 mg/g・Cr) in NIDDM. In conclusion, serum type IV collagen is helpful as a early indicator of nephropathy.

Journal

  • VITAMINS

    VITAMINS 70 (5-6), 235-240, 1996

    THE VITAMIN SOCIETY OF JAPAN

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