Safety assessment of probiotic bacteria, <i>Bacillus coagulans </i>strain SANK70258, in rats
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- Akagawa Yui
- LSI Medience Corporation
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- Ohnishi Yasuyuki
- LSI Medience Corporation
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- Takaya Masatoshi
- Mitsubishi-Kagaku Foods Corporation
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- Watanabe Yuko
- Mitsubishi-Kagaku Foods Corporation
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説明
<p>Bacillus coagulans is a lactic acid, spore-forming gram-positive bacteria that has the potential of probiotic benefits. To evaluate the toxicological profiles of Bacillus coagulans strain SANK70258 (active element of LACRISTM-S), a 90-day oral gavage dose study was conducted in rats. The microbe was administered by oral gavage to 6-week old Crl:CD(SD) rats (10 males and 10 females/group) for 90 days at dose levels of 0, 500, 1000, and 2000 mg/kg/day. According to the results, no deaths occurred in either males or females, and no treatment-related changes were observed in any clinical sign including a detailed observation with functional observational battery (FOB), functional test, motor activity, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, blood chemistry, organ weight, necropsy or histopathology. In conclusion, Bacillus coagulans strain SANK70258 had no subchronic toxicity in rats and the no-observed-adverse-effect-level (NOAEL) was judged to be greater than 2000 mg (about 1 × 1012 CFU)/kg/day. The microbe is harmless and can be used as a probiotic.</p>
収録刊行物
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- Fundamental Toxicological Sciences
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Fundamental Toxicological Sciences 3 (6), 243-250, 2016
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282680739991040
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- NII論文ID
- 130005431440
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- ISSN
- 2189115X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
